Ebolavirus and Marburgvirus: Insight the Filoviridae family
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چکیده
منابع مشابه
Ebolavirus and Marburgvirus: insight the Filoviridae family.
Ebolavirus and Marburgvirus (belonging to the Filoviridae family) emerged four decades ago and cause epidemics of haemorrhagic fever with high case-fatality rates. The genome of filoviruses encodes seven proteins. No significant homology is observed between filovirus proteins and any known macromolecule. Moreover, Marburgvirus and Ebolavirus show significant differences in protein homology. The...
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background microsatellites have evoked the interest of researchers owing to their applications in different fields such as dna fingerprinting, genetic mapping, population genetics, forensics, paternity studies and evolution. objectives the present study focused on the analysis of simple sequence repeats (ssrs) in genomes of seven species from three genera of the filoviridae family. materials an...
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The Egyptian rousette bat (Rousettus aegyptiacus) is a natural reservoir for marburgviruses and a consistent source of virus spillover to humans. Cumulative evidence suggests various bat species may also transmit ebolaviruses. We investigated the susceptibility of Egyptian rousettes to each of the five known ebolaviruses (Sudan, Ebola, Bundibugyo, Taï Forest, and Reston), and compared findings ...
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Viruses in the Ebolavirus and Marburgvirus genera (family Filoviridae) have been associated with large outbreaks of hemorrhagic fever in human and nonhuman primates. The first documented cases occurred in primates over 45 years ago, but the amount of virus genetic diversity detected within bat populations, which have recently been identified as potential reservoir hosts, suggests that the filov...
متن کاملConserved receptor-binding domains of Lake Victoria marburgvirus and Zaire ebolavirus bind a common receptor.
The GP(1,2) envelope glycoproteins (GP) of filoviruses (marburg- and ebolaviruses) mediate cell-surface attachment, membrane fusion, and entry into permissive cells. Here we show that a 151-amino acid fragment of the Lake Victoria marburgvirus GP1 subunit bound filovirus-permissive cell lines more efficiently than full-length GP1. An homologous 148-amino acid fragment of the Zaire ebolavirus GP...
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ژورنال
عنوان ژورنال: Molecular Aspects of Medicine
سال: 2008
ISSN: 0098-2997
DOI: 10.1016/j.mam.2007.09.005